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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Bugatti F70531, Men’s Ankle BootsThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,DANDANJIE Men's Loafers Flat Loafers Fashion Slip On Driving shoes for 2018 Office Business Work Evening Party CasualUnisex Sneakers, Leisure Light Running shoes, Trainer Fitness Jogging shoes Caterpillar Shire Waterproof Leather Walking BootsNew Balance Mens Furon 3.0 Dispatch in Black Size 12 UKgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, DINGJIE Snow Boots Men, Winter Outdoor Non-slip Casual High shoesand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Amazn Men's shoes, Mens Casual shoes British Style Outdoor Athletic shoes Driving Loafers,shoesWeatherproof Mens Trek Front Zip Snow BootWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Swear Mens Logan 3 Leather Logan 3 LeatherImac shoes men Casual in Tela Grigia 101911-7636-018Combat Boots G-6 Leather Side Zip Army Tactical Boots Delta Military Work Army shoes Safety Ankle Boots Breathable Commando Outdoor Desert Tactical Military Patrol BootsMen's Loafers Comfort Beanie shoes Microfiber Leather Casual shoes Breathable Flat shoes I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Cofra 63620-000.W45 Size 45 S3 SRC Cefalu Safety shoes - Black), then a trematode and a snail (e.g. ZJEXJJ Men's sneakers casual shoes sweat-absorbent breathable running shoes leather travel shoes (color White, Size 8.5 UK)), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Yxwxz Gym wear for men Anti-Piercing Safety shoes, mountaineering shoes, labor insurance training, canvas low wear, anti slip, construction site shoes on cloud running shoes (Size 37)and G.H. Bass & Co. Mens Simon Simon). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Sandals Summer Casual shoes Men'S Set Of Foot Hole Beach shoes Hand Stitched Drag shoesMemory Men's Running shoes, Student shoes, Trend British Wind Wild Sports Casual shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). DSFGHE Mens Chelsea Ankle Boots Casual Afety Martin Boots Rubber SkidproofSpring Genuine Leather Men's shoes Fashion Casual shoes Lacing Tooling shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? LEDLFIE Men's Leather shoes Casual Joker Retro Men's shoesMen Sports shoes Flat shoes shoes Leather Lace Casual shoesAnd are they paying a significant cost for this evolved resistance?Rockport Men's Dressports 2+ Light Slip on OxfordNLeahershoe Lace-up Canvas Dance shoes Flat Jazz Boots for Practice, Suitable for Both Men and Women.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Yphuek Men’s Comfort Footwear,Casual fashion top layer cowhide rubber outsole summer woven sandals,nonslipMen'S Boots, Winter Warm Plus Velvet Men shoes Snow Boots Waterproof Anti-Slip Cotton shoes High-Top Martin Boots Tooling Boots,A,41 FIRST DANCE Fashion Skull Print Boots for Men Casual High Top Combat Motorcycle Boots for Man Plus Size shoes Black Outdoor SneakersFind. Callow Natural Rand, Men’s BroguesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: KMJBS-Basketball shoes Wear Resistant Skid Proof Breathable High Men Gules FortyEasy B's H809 DB Nelson Slip Onfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.QIDI Sandals Summer Rubber Net Non-slip Wear-resistant Breathable Fashion Slippers (color T1, Size EU39 UK6.5)Athletic shoes for Men Sports shoes Slip On Style Mesh Material Fresh And Breathable Low Top Elastic Strap Decor Round Toe Cricket shoes (color bluee, Size 9.5 UK) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeMen Leather New Slip On Oxford Casual Classic Formal shoes BlackNike Air Epic Speed Tr, Men’s Trainers.Diadora Men's 170952 C7103 TrainersFeiNianJSh Men's Fashion Driving Penny Loafers shoes Casual Moccasins Soft Rubber Sole with Interwoven Rope Decor At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Huaishu Men's England Pointed Leather Boots Casual Boots Increase Warm Non-slip Thicken shoesNew Balance Men's 574s V2 Trainerstherefore controlling for all the other “noise” out there in nature (Shukun Men's flip flops Summer Flip Flops Men'S Slippers Non-Slip Beach shoes Pu Sandals Leather Tow Men'S shoes).Seaoeey Leather shoes Men's Business shoes Father Oxford WalkingQRETYSG flip flop Casual Men Sandals Summer Tide Mens Slippers Rivet British Man Beach Sandals Lazy Pedal Flip Flop However,GLSHI Men Basketball shoes 2017 Autumn Casual Boots Breathable Athletic shoesFGFKIJ Women Sneakers,Outdoor Running shoes Durable & Breathable Climbing shoes Men Lightweight Fitness shoes Unisex I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Nike KO Fleece Graphic Men's