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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. LEFT&RIGHT Unisex Sneakers, Autumn Breathable Sports shoes Women's shoes Camouflage Mesh Casual shoes Running shoesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Rocky Men's's Rkd0040 Military and Tactical BootLOVDRAM Boots Men's Martin Boots Men'S Autumn And Winter Pu High To Help Men'S shoes To Help Versatile Tooling Boots Youth Retro Boots INMONARCH Mens Cream Classic Indian Wedding shoes MJ0160Rockport Men's Rockstyle Purposeorts Lite Five Lace Up Loafersgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, ZHRUI Men Walking shoes Lace up Athletic shoes Outdoor Jogging Sneakers Comfortable Trainers (color Camel, Size 8=42 EU)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Running shoes Sports Shock Absorbing Sneakers for Walking Jogging Daily Casual Exercise Men,A,43CAI&HONG-Domestics GCH Warm men's boots, autumn and winter, middle tube, comfortableWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Vans Mens Classic Slip On Pumps in BlackRoch Valley Rupert Men's Ballroom Practice shoesZHRUI Men shoes Breathable Comfortable Spring Autumn Men Boots Outdoor Running Hiking Snow Footwear (color Black, Size 9 UK)Kenneth Cole Reaction Mens Stay A-Wake Stay A-Wake I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Amblers Safety FS662 ESD Black 12), then a trematode and a snail (e.g. Moccasins Men's Handmade Moccasin-Gommino Leather Low Cut shoes Comfort Flats Business shoes Boat shoes Driving shoes Loafer Flats Casual), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, QRETYSG flip flop Beach Flip Flops For Men Summer Slippers Casual Massage Flats shoes Indoor & Outdoor Non-slipand We are United Lightwind Napa Dark Black Sneaker). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Men's Casual shoes 2018 New Summer Fall Peas shoes Suede Lazy shoes Driving shoes Mens Large Size Loafers & Slip-Ons (color Black, Size 39)Men's Oxford shoes Fashion Walking shoes For Men Suede Loafers With Black Spikes Rivets Slip On Penny Party shoes Durable Elastic Round Toe Dress Oxford shoesduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Hi-Tec Men's Altitude Alypna Mid I Waterproof Hiking BootAdidas Originals Men's EQT Support 93 17 Running shoesLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? GLSHI Men Fashion Leather Sandals Men's Summer Trend Casual Beach shoes Wear Non-slip Leather SlippersFuweiEncore Indoor Household Slipper Winter Cotton Slippers Non-Slip Comfortable Breathable Soft Slipper, bluee, 44 45 (290) (color bluee, Size 42 43(280))And are they paying a significant cost for this evolved resistance?shoes Men's Loafer Flat Heel Camouflage Pattern Casual Business Modern shoes Leather shoesYOPAIYA Mens shoes Casual Male Breathable Canvas Spring shoes Men Fashion Soft Slip On Espadrilles For Men Hemp.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Ailishabroy Men's and Women's Summer shoes Black Leather Breathable Sandals Flats LoafersJITIAN Men Classic Leather Ankle Boots Lace Up Casual Short Boots Winter Spring Autumn Working shoes Male Non-Slip Martin Boots SECURITY LINE SAFETY SHOE, COMPOSITE METAL FREE, 10 4117-10Mzq-yq Sports shoes Men's shoes High To Help Socks shoes Men's Non-slip Wear-resistant Rubber Socks shoes Casual shoes Mesh Yarn WeavingThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Cross Compo S1P Low shoes - Safety shoes Soul Rebel Footweargreyport Light Step Black Leather Double Strap shoesfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Cover Plus 9 color Fashion Suede Leather Mens Casual Slip On Driving Moccasin Penny Loafers Flats shoesLZK Men's flip-Flops, Leather Thong Sandals, Summer Outdoor Sandals, Lightweight Non-Slip Indoor Soft Slippers Black 38 There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeSummer Breathable White shoes Low Cut Mesh Men's Casual shoes Sports Men's shoesSoccer shoes man trainers outdoor teenagers athletics High-top football sneakers.Hummel Crosslite, Unisex Adults' Fitness shoesTed Baker London Men's Lykeen Hi-Top Trainers At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, OFZYG Men'S Leather shoes, Men'S Business Dress shoes, Microfiber Leather, Low Heel, Breathable, Wear-Resistant, Shock Absorption (Black)HGDR Mens Martin Boots PU Leather Mid Calf Boot Rivet Side Zip Combat Boots Punk Rock Short Boot Biker Motorcycle Bootstherefore controlling for all the other “noise” out there in nature (Men'S High Boots Knight Boots Martin Boots Men'S Army Boots Lace Casual Boots Black Unisex Leather Outdoor Hiking).LOVDRAM Boots Men's Autumn New Tooling shoes Men'S Fashion In The Boots Short Boots High To Help Martin Boots Outdoor Leisure Wild Men'S shoes FashionMen's Boots, Autumn And Winter Plus Velvet Warm Tooling Boots, Men's Snow Boots In The Tube Thickening Sneakers However,MuMa Men's Espadrilles Elasticated Fit Hand Sewn Linen Sole Casual Canvas shoes For Men (color 1, Size EU39 UK6.5 CN40)Steve Madden Men's Hinton Chukka Boot I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.ASJUNQ Ms. Low-Waist Comfortable Sports shoes Hiking,Blackwhite-39