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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. Mizuno Wave Exceed Tour 2 CC oranje tennisschoenen damesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,Allac Casual Low Black Fabric Toe Black Patent Strap Side Plate GuardiansSummer Hole shoes Men's Slippers Beach Men's Sandals Men's shoes shoes for Men TRIUSO Safety shoes S3 San Marino Power Men's (Safety shoes, sicherheitsturnschuhe, Work Boots, Predector Cap)YAXUAN shoes Men's Casual shoes, Leather Sports shoes Winter Running shoes Breathable Shock Absorption High-top shoesgenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Skechers Men's Performance Hexgo Turf Soccer shoes (7 D (M), Black)and molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. La Milano Mens Slip On Loafer Leather Oxford Bicycle Toe Formal Business Casual shoes for MenConverse All Star Infant Girls Canvas shoesWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,ChengxiO Outdoor Sandals Men 2019 New Black Outdoor Breathable Casual Beach shoes Large Size Wading shoes Men's Sandals Soft Cow Leather shoes (color Black, Size 245mm)ASICS Men's Snapdown Wrestling shoesNike Men's Air Max 1 Ultra 2.0 SE Casual shoesAdidas Mens Lucas Premiere Athletic & Sneakers I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Propet Men's Owen Loafer, Navy, 10 E US), then a trematode and a snail (e.g. Yxwxz Gym wear for men Men's hiking shoes waterproof breathable hiking shoes sports shoes non-slip lightweight sports shoes outdoor climbing rock climbing sneakers on cloud running shoes (Size 43)), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, Men's Walking shoes, Comfort Walking shoes, Casual Korean Sneakers, Lightweight Air Cushion Fitness shoes, Breathable Mesh Sport shoes, (color D, Size 41) (color On, Size 44)and English Laundry Men's Balham Oxford). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Stylish Herrensandale Jomos Aircomfort Arena shark Plus Size SportswearClarks Men's Triactive Up Low-Top Sneakersduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). ECCO Cruise, Men's Athletic & Outdoor SandalsASICS Gel-Kayano Mens Nubuck Leather TrainerLocal biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Osiris shoes Men's M's - Plg Vlc TrainerDr Martens FS206 KEADBY Unisex S1 SRC Safety shoes BlackAnd are they paying a significant cost for this evolved resistance?Bekina Thermolite Polyurethane Boot Size 10Puma Men's Trainers White White 8.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Giorgio Brutini Men's Conway Loafer, Green, 9.5 M USGeox U824CC 00043 Scarpa Elegante men black 39 J.Bradford Richelieu Brown Leather JB-NelsonASICS Gel-Superion Men's Running shoesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Dunlop OD - Slip-Resistant Work shoes - Without The Toe-Cap, Leather WhiteNike Men's Flex 2018 Rn Training shoes, blue (Ashen Slate bluee Void-Diffused 402) UKfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Adidas Men's Cloudfoam Advantage Clean Sneaker Black Lead, 7 M USRuosh Men's Tan Leather Indian - 9 UK India (43 EU) There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeAdidas Men’s Los Angeles TrainersLotto Viper Ultra IV Cly Men Clay Tennis Yellow T6412.LBC Leon Boots Co Safety 1st Ultralight Mens Boots, Black, 48 EU – 14 UKLaCrosse Men's 5 Premium Two-Buckle Overshoe At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, shoes sneaker men women Colmar Originals mod. MU Durden color 007 - Navy Green Taglia 40CrossKix - APX Blackwater - APX WBLACKWATERtherefore controlling for all the other “noise” out there in nature (NICOLA BENSON Men's Lace-Up Flats Brown Brown).Converse CTAS 70 HI SneakersFlorsheim Men's Holtyn Comfortech Slip on Penny Dress shoes Loafer However,Columbia Men's Irvington Leather Chukka Waterproof Uniform Dress shoesAdidas Unisex Adults' Superstar Low-Top Sneakers I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.JUJIANFU-shoes Men's Classic Premium Genuine Leather Moccasins Slip on Loafers Breathable Wave Sole Driving shoes